Relics changed a lot in S8; setups include Shadow weapon-based DPS with Skull Axe, Death's Scythe, Shiv, Commander’s Sword; Setup 2 and Setup 3 offer alternatives for vandalization of mobs and for greater damage; Setup 4 is defensive.

Cover page

Q: What armor augment to choose?

Use Divine Piercing on angelic keys; helps map clear but not essential early. Video demonstration provided.

Q: What to do on the Hero Level skill tree?

Refer to Leveling progression page for Poison and to Transition page for Physical build.

Q: What to do with free sockets?

Follow six-step socket guide including Moonstone gems, Deadly Blow checks, Life/Mana stolen checks, angelic gems, resistance checks, and final choices between damage and survivability.

Q: How to distribute attribute points?

Poison: Energy to 200 mana, then Intelligence, then Vitality. Physical: 300 into Vitality and 100 into Strength.

Q: What mercenaries to choose?

Poison: Act 1; Physical: Act 3; special notes for swapping to Act 1 for magic find in late game.

Q: What loot filters to use?

Season 8 loot filters updated; leveling filter provided; detailed filter rules and link included in the guide.

Welcome to my Plague Doctor guide for Season 8!

This guide covers the physical attacker archetype , if you’re looking for the poison caster build, check my other video. Youtube channel: https://www.youtube.com/@Proerd-iKappa

Important: For a better reading experience do the following:

Click on View; hover over Text width; then click on Wide This should make the guide better to read

Really happy with how this format worked out, so I'm keeping it like that for Season 8. Big shout out to the #plague-doctor-discussion channel in Hero Siege’s discord, a lot of valuable insight coming from the community was put into this guide, making it pretty much a benchmark guide. Here you will find more in-depth explanations about how to progress the best way possible with Plague Doctor’s physical attacker archetype, which is in my opinion, leveling and grinding early-mid game as a Poison caster, then swap to Physical only after you get a good weapon and angelic key armor augment (more information on the Transition to Physical page), this document will be updated during the season.

Plague Doctor is a DLC class in Hero Siege, featuring options to play as a poison-themed spell caster or a knife throwing/stabber physical attacker.

Physical build pros: Very tanky due to %life passives, toxic flask buff, and life steal, gets huge movement speed from booster shot and randy rider, very good all-arounder class, with good single target damage and clear speed, can scale damage through vitality stacking, does not have many buttons to press, very consistent damage output. Physical build cons: Leveling with the physical build can feel bad, so we use the poison build to level and acquire gear to eventually swap, playing without divine piercing augment feels bad, capping resistances is rough with physical classes, physical gear can be expensive on trade.

Poison build pros: Very strong season starter, will feel great to play right after you unlock the sub-skill augments, excellent boss killer, gets decent movement speed from randy rider, can use teleport gear, has an easier time capping resistances, very tanky due to %life passives, toxic flask buff, and HP recovery from Jar of Leeches, poison gear is usually cheap on trade. Poison build cons: Has more buttons to press in comparison to the physical build, relies on mana potions against bosses, relies on keeping Crematus uptime for maximum damage, damage output can feel inconsistent since you rely on poison break and poisoned debuffs from Crematus.

Conclusion: If you want to use less buttons and prefer a more braindead and smooth gameplay, go for the physical build. If you want a very solid boss killer and don’t mind pressing more buttons, go for the poison build.

It was one of the best classes in Season 5, 6, 7, and will be one of the best in Season 8 as well. I'm dedicating a page to talk about what changed in Season 8 and how it impacts us.

On this sheet you will find the following contents for the physical build: ● What changed in Season 8 ● FAQ and Loot filters ● Leveling and mid-game progression as a Poison caster ● How to transition into the Physical build ● Scaling into the endgame ● Best in Slot item sets (soon) Navigate through them by changing the document pages on the left side.

Helpful content below:

S8 Poison Plague Doctor guide video: https://youtu.be/RwDDIslB3es S8 Physical Plague Doctor guide video: https://youtu.be/WY2ch7zlB-c Level 0 100 full run in Season 8 open beta : https://youtu.be/mfjJNooYjdw S7 guide video: https://www.youtube.com/watch?v=JRZbSDT_q0g S7 Day 3 wormhole 100 completed https://youtu.be/hnOxJ4_WbdM S7 Unlocking Inferno (H5 Amun Ra + Gabriel fights) https://youtu.be/6Yvccf-K9z4 Level 0 100 full run in Season 6 : https://youtu.be/h-l02BSbnHA S6 H5 Uber Reaper with no SS tier items (Poison build): https://youtu.be/vXsWtS9xDjI S6 H5 Gabriel with no SS tier items (Poison build): https://youtu.be/1PgVct_2dZc S6 guide video: https://youtu.be/G5da8gCxG7Q S6 Day 1-2 SSF build update: https://youtu.be/xor3YXApiWU?si=ZAvqlOUvowlCihIG S6 My first uber boss showcase: https://www.youtube.com/watch?v=ddLuIF3t6Aw Final S6 update Wormhole 100 completed on day 3: https://youtu.be/3Kna-dpD8f4 Endgame Physical Plague Doctor showcase (S6 footage): https://youtu.be/mnAg9raufJ4

What changed in S8?

What changed in Season 8?

(Only covering big changes related to character power that affects mainly Plague Doctor’s physical build)

really nice one

A small buff to the physical build.

Molten Paw swap is only useful now for bossing, since only the merc’s basic attacks will be able to burn.

A relevant nerf to the physical build, this Surgical Blood Letting proc is going from 100% to 60% vitality conversion, by doing some quick testing I estimate that to be a ~15% damage nerf on a well built character (with over 600 vitality), spending points on strength becomes much more viable now. Even though it is a relevant nerf, the physical build will definitely be still very strong, especially if you consider scaling more strength instead of vitality, my recommendation now will be spending the attribute points as a 3:1 ratio of vitality to strength (300 vitality, 100 strength)

FAQ and Loot filters

FAQ Frequently asked questions | Loot filters (highlight only)

What relics to use?

Relics changed a lot in S8, feel free to experiment with them, here is my personal choice looking at them:

Setup 1 Meant to use with a shadow weapon for maximum damage (recommended to start) Skull Axe (Demon Form proc) | Death's Scythe (Agility proc) | Shiv (Live by the Sword Proc) | Commander's Sword After you get Legionnaire helmet, feel free to replace Shiv with Rock Belt

Setup 2 Meant to use with any weapon for maximum clear speed The Amputation Kit | Rock Belt | Death’s Scythe | Shiv After you get Legionnaire helmet, feel free to replace Shiv with Monkey King Bar

Setup 3 Meant to use with a non-shadow weapon for maximum damage Skull Axe | Nunchucks | Twin Blade | Razer Blade

Setup 4 Defensive setup Cheese Burger | Mayo’s Old Sock | Cookies & Milk | Skull Axe

What armor augment to choose? (Angelic Key)

Save up 6 angelic keys and go for Divine Piercing, it makes Surgeon Vortex blades not disappear, greatly improving map clear, it is not worth going past level 1 though, I'm almost sure that the armor break coming from it is irrelevant due to already having crushing blow. Video showcasing the augment: https://www.youtube.com/watch?v=e2nQMRA4AL8

What to do on the Hero Level skill tree?

Find hero level skill trees at the Leveling progression page for the Poison leveling build, and Transition to physical page for the physical build.

What to do with free sockets? (Physical build)

Step 1 On weapons you ALWAYS place Moonstone gems Step 2 Check if you have 100% Deadly Blow, if not, place Xo runes Step 3 Check is if you have more than 0% Life/Mana stolen per hit, if not, place a Pristine Skull/Vex rune Step 4 Place an angelic gem on every item, only exception are rainbow sockets Step 5 Check if your resistances are capped (75%), if not, place Um runes Step 6 Personal choice, if you need damage: Pristine Diamond; if you need survivability: Jah

How to distribute attribute points?

Attribute points are a personal choice for the poison build , I personally like to get Energy until 200 mana, then Intelligence until I can one shot trash mobs, rest goes into Vitality. For the physical build you put 300 points into Vitality and 100 into Strength (3:1 ratio).

What mercenaries to choose?

For poison build use the Act 1 mercenary (skill tree in Leveling progression page) For physical build use the Act 3 mercenary (skill tree in Physical build transition page)

What loot filters to use?

Loot filters got updated in S8.

I made for now just a leveling one from closed beta, hopefully it works when the season releases, i highly recommend you read the entire guide and make one based on what the character needs, but below i will keep posting the filters i use during the season:

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Leveling progression

Leveling progression as Plague Doctor

The best way to level a Plague Doctor is by being a poison caster archetype , using skills on the Plague Caller side of the skill tree. Your damage here will scale through mainly Skill levels, Intelligence, Flat poison skill damage , Poison/Magic skill damage%, ignoring enemy poison resistance, and faster cast rate, so search for items with those stats. The first thing you do after creating your Plague Doctor is setting up your loot filter. Highlight those stats on all items: All Skills | Poison Skills | Flat Poison Skill Damage | Intelligence per level | Faster cast rate. After highlighting on all items, add those modifiers on the Charm highlight: Intelligence | Life | Life% | Mana | Life/Mana after each kill | Arcane/Poison/Fire/Lightning/Cold/All resistance | Faster cast rate | Magic Skill Damage. Find the filter link on the FAQ on the previous page. (it might not work since i made it on S8 beta)

The attribute points distribution is a personal choice, after my main skill gets to level 20 i like having at least 200 mana, so i put points into Energy until 200 mana, then i put points into Intelligence until the weakest mobs die on a single cast, all other points go into Vitality. If you're playing on Hardcore, all points go in Vitality.

Tip: When changing equipment, ALWAYS look at your damage tooltip (hover your mouse over your skill), be careful to not reduce your damage.

Tip: Keep an eye on Runewords while leveling, here are a few good ones: Skysong weapon/shield (4 sockets) | Divine contemplation shield (3 sockets) | Divinity (4 sockets 1Handed Mace) | Scholar helmet (2 socket) | Ghost boots (2 socket) | Toxicarcus armor (3 socket)

Tip: Each 5 levels you gain a specialization point to use on your skills Here is how you use them before Level 40 Crematus: 3/3 Gas Cylinder -> 1/3 Potent Exhaling Plague master: 5/5 Plague Domain -> 2/5 Toxology Jar of Leeches: 5/5 Leech Swarm -> 2/5 Power Sucktion

Level 1 24: Put all your points into Crematus until maxed, then other points into Toxic Flask

Level 24-39: Here you start using two skill trees, #1 for zone clear and #2 for act bosses and bloating mobs.

Tree #1 Zone Clear Tree #2 Act bosses + Bloatings

20 points into Plague Master [Careful since it uses a lot of mana (get at least 200 mana)]

Other points into Chant of Weakness

On level 35 unlock the Toxic Flask teleport specialization (Flask Flip)

20 points into Jar of Leeches

Other points into Plague of Rats

Level 40 respec: Here you unlock the specialization big nodes, only a single skill tree will be used for both zone clear and bossing. The playstyle will be keeping Crematus 100% uptime to clear all the trash mobs while debuffing the tanky mobs with poisoned and poison break, Jar of Leeches is used as a main damage dealer against bosses and tanky mobs, Randy the Rancid Rat is used for a movement speed buff, and Toxic Flask is used for a small health and damage reduction buff, it is also used as a teleport.

Plague of Rats is an optional skill choice for bosses, with the Rat Den node you can keep enemies with a 25% higher poison break compared to Crematus poison break, giving you a slight damage boost.

20 points into Crematus

1 point into Toxic Flask

1 point into Oops

1 point into Plague of Rats

1 point into Exploding Mice

15 points into Jar of Leeches

1 point into Randy the Rancid Rat

Pictures of the specialization trees below:

Level 40-100: Based on the level 40 respec tree above, do the instructions below in order from top to bottom and you will be fine until level 100:

Max Jar of Leeches

Max Chant of Weakness

Max Crow Mask’s Presence

1 point into Lifeblood Aura

With the 14 points you have left, there are two options, pick whatever you prefer:

Put 14 points into Toxic Flask for more Crematus damage

Put 14 points into Lifeblood Aura for more Health

Specialization tree priorities: Crematus: 5/5 Trifurcate Blow 3/5 Corrosive Embers 2/3 Spiraling Cremation (Level 70) 5/5 Corrosive Embers 3/3 Gas Cylinder 2/3 Potent Exhaling 3/3 Spiraling Cremation (Level 100)

Toxic Flask: 5/5 Agile Tosser 1/5 One with the Poison 2/3 Vial of Alchemy (Level 70) 5/5 One with the Poison 3/5 Flask flip 3/3 Vial of Alchemy (Level 100)

Plague of Rats: 5/5 Leptospirosis 3/5 Plague Carriers 2/3 Rat Den (Level 70) 5/5 Plague Carriers 5/5 Horde of Rats 3/3 Rat Den (Level 100)

Jar of Leeches: 5/5 Leech Swarm 1/5 Blood Sharing 2/3 Lasting Hunger (Level 70) 5/5 Power Sucktion 2/5 Bloody Surprise 3/3 Lasting Hunger (Level 100)

Randy the Rancid Rat: 2/3 Randy Rider (Level 70) 3/3 Randy Rider (Level 100)

Use the screenshots below as a reference to how the build should look like at level 100:

Alternative spec skill tree for Crematus (better on zones that you aren’t instakilling stuff))

Hero Level skill tree:

1st step is grabbing those

2nd step is going all the way up and grabbing those

3rd step is either grabbing those points or going for the charm slots, personal and situational choice Mercenary skill tree (Act 1): Use magic find items on him if possible

Midgame progression

Midgame progression with the Poison build

Just like before, the plan is still to farm enough poison gear to make it viable to kill H5 Uber Reaper on season start, so we acquire its Shadow weapons , which are in my opinion mandatory weapons to use now early on in the physical build. Important: If you are starting the season late, shadow weapons become much cheaper, so you can bypass the usual grind and swap to physical much earlier. Find more information on the physical build transition page.

This section of the guide will be focused on gearing progression and important mechanics to consider when choosing the items.

Main stats to focus on your gear to increase damage: Skill levels, Flat poison skill damage, Intelligence, Magic/Poison skill damage%, Faster cast rate%, Ignore poison resistance%, Extra damage to poisoned enemies% ● Ignore poison resistance% caps at 100%, it is very important to cap this stat ● Life/Mana on kill are good sources of sustain while clearing zones Find more in depth information about how spell damage is calculated on this site: https://hero-siege-helper.vercel.app/damage

Just like the previous guide, to avoid market manipulation I'm listing multiple viable options to choose, ALL OF THEM ARE GOOD, they are listed randomly, there is no distinction if one is better than the other if they are on the same tier, try to find good opportunities to spend less gold if you’re playing trade.

Everything is updated according to how the items look like in S8 open beta, but feel free to contact me if i missed something.

I'm listing all the good items to use as a tier list from B to S. ● B tier: Good to progress through all Hell 1 levels and possibly defeat H3 Mevius ● A tier: Probably good enough to defeat H5 Uber Reaper ● S tier: Items to use if you need a further damage boost, items here might be expensive Remark 1: I’m only considering the impact of those items for damage. Remark 2: I’m not listing mythic/rare items , but all of them can range from A to S tier if they have good affixes, here is a small list of them with the respective maximum rolls: +5 all skills | +30% extra damage to poisoned | +50% faster cast rate +50% magic skill damage | +50 intelligence per level | +5 poison skills

Item type B Tier A tier S tier

Weapon Cobra Blood Vial Skysong runeword (1 handed) Wormclaw Sands of Time Voodoo Magician's Skull Brilliance runeword

Clafaxier Doomweed Vial Divinity runeword Dragon Knight's Flail Deathquill Thorn of Helheim Damien's Head God's Benevolence

Virulence runeword Clafaxier's Legacy Pagan God's Blasphemy Beacon of Shadows Clafaxier’s Legacy Serpent's Tooth Oculus of Ages Steve's Wand of Fortune Grief runeword Pagan God’s Blasphemy Damien's Corrupted Head Doctor's Potion

Shield Skysong runeword Pandemic Shield Arcane bastion runeword Novice’s Tower

Ancient Aegis Defender’s Justice Ward of Toxicity Heaven’s Champion

Bubonic Plague’s Pledge runeword

Shadow Buckler Iron Giants Shield Battle Mage’s Shield Spellbinder’s Magebarrier Suomi Finland Suatana

Suomi Finland Perkele Aztec Ward

Armor Toxicarcus runeword Shroud of Enigma runeword Mystify runeword Magister’s Robe Hazmat Suit Arcane Robes of Authority Scourge Gladiator’s Armor Grandwizard’s Robe

Heaven’s Might Grimbone's Ribcage Isarius Ironthorn Breastplate Mystique Allure Stoneplate of Corruption Traveler's Leather Jacket

Gem King’s Garb (Pristine emerald) Noxious Hunter’s Reward Sheep King’s Hide Venomsteel Carapace Wraith’s Cloak (Poison) Dragon Knight's Vanguard Exiled Pagan’s Mantle

Helmet Chimera runeword Harlequinn’s Crest

Crown of Midnight The Curator of Secrets

Sheep King’s Crown Eternal Death Sight of the Gods Curse runeword Delirium Tremens runeword Nirvana runeword Grimbone’s Visage Harlequinn’s Veil

Boots Paradox runeword Ghost runeword Hermes boots Mana-woven walkers Arch Wizard’s Silk Boots

Ninja tabi runeword Marchers of Hatred Adamant Roamers Pearlescent Dream Voodoo Stompers Grand Wizard’s Silk Shoes Wind Walker’s Step

Etherwalk runeword (poison)

Gloves Conjurer Mitts Battle Caster’s Gauntlets Lifeward Gauntlets

Mevius’ Mighty Gauntlets (Poison) Anubis’ Mighty Hands Wisdom’s Hold

Shadow Occultist’s Wraps Spellweavers (Poison) Fighter Magi’s Grips Plague Bringer’s Touch

Belt Lich Sash Crystal Belt Commander’s Sash Knight’s Girdle Sash of the Magi Runemaster’s Waistwrap Traveler's Double Belt

Tether of Anguish Cingulum of Shifting Destiny Komodo’s Bloodstrap (poison) Trophy Hunter

Girdle of Eternal War (Poison) Majorie’s Belt

Amulet Damien’s Soulstone High Demon’s Necklace Arcana Eye Gambler’s Demise Rapidshell Medallion Ritual Pendant Shining Pearl Serpentine Necklace

Aztec Necklace Visage’s Eye All seeing eye Claw of the Hunter Rift Warrior’s Skull Light Bringer’s Mark Lilith’s Scorn Traveler’s Compass Unfathomable Puzzle Venom’s Necklace

Steve’s Necklace Philosopher’s Stone Pendant of Eternity Tarethiel’s Fall

Rings Satanic Eye Swiftsoul Band Viper’s Seal of Corrosion Merlock’s Halo Circle of Nature

Khodo’s Wedding Band Iron Ring of Prometheus Mark of Ferocity Ring of Tallus Stone of Premonition

Giant’s Band of Strength Quickening Zephyr (Plague Doctor) Soulforged Ring Signet of Corruption The Absence of Constraint

Charms Damien’s Cage Traveler’s Map Journal Crow’s Feather

Doctor’s Mask in a Jar Loaded Dice Shrunken Head Witches Claw

Apple of Evolution Hello Its me, Steve! Torstein’s Anvil Tablet of Awakening Chaos Gemstone Devil’s Pact Overloaded Dice Mysterious Monkey Paw Rotten Pumpkin Dragon’s Heart

Annihilator Fulgurite Torch of Shadows Sheep King’s Wool Wizard’s Dice Sassy’s Dislocated Foot Tarethiel’s Ancient Wisdom Soul Collector

Flasks Ghostly Potion Elixir of Death Wizard Potion

Empty Bottle of Vodka

Key advices before fighting H5 Uber Reaper

● The “Shadow Skull” attack is very hard to dodge, it's better to just tank it, due to that i recommend you get around 4k health and 75% arcane resistance before fighting it

● Uber Reaper has a dps check, the “Shadow Lantern” summon, where Reaper becomes invulnerable and starts to recover HP while the lantern is alive, so you gotta make sure you kill it as fast as possible, due to that i suggest you make sure to this DPS requirement: IGNORE ALL THE INFORMATION BELOW, UBER REAPER WILL GET A BIG BUFF IN S8, WILL UPDATE SOON

OUTDATED!!!

Go to Shujo Retreat, swap for the bossing skill tree, reset your DPS meter, and start throwing only Jar of Leeches for around 30 seconds into the target dummy , if your DPS meter is above 20 million , you’re able to get past Uber Reaper’s DPS check and defeat it. I wouldn’t say this is the minimum requirement, but it's enough for a somewhat easy fight, lasting around 2 minutes. This should be achievable by using the A tier items.

● During the fight, try to save the Rat Den to when he spawns the Shadow Lantern, which is right after the “Execution” attack, find more details on this fight against H5 Uber Reaper: https://youtu.be/vXsWtS9xDjI ● With all this information you should be ready to farm H5 Uber Reaper until a Shadow weapon drops, then it is time to transition into the Physical build, time to go into the next page.

Physical build transition

Transitioning into the Physical build

Time to swap into a completely different Plague Doctor build.

● Core mechanics explained:

The skills used here are the following:

Surgical Blood Letting as the main damage dealer

Toxic Flask used to teleport and buff our health and damage by a massive amount

Defunct Surgeon used to give a small attack speed buff

Randy the Rancid Rat used to give a movement speed buff

The main skill of this build is Surgical Blood Letting, a physical attack with built-in Vitality damage scaling through a specialization node.

Physical attack rate is based off your weapon’s base attack speed, and it can be increased by raising your %increased attack speed:

It is important to know that the %increased attack speed affix on weapons increases the weapon’s base attack speed , while the same affix on other items increase the global increased attack speed , so a %increased attack speed affix will always have much more value on weapons compared to other items.

The bottom stat is the global increased attack speed, which is multiplied by 0,75 before being added into the attacks per second stat

Physical attacks can miss enemies, and what determines if you hit an enemy is their defence compared to your attack rating, enemies defence scale exponentially based on zone level, that is one of the reasons we are using Shadow weapons at the beginning of the transition, to not care about that stat since they give 100% hit chance.

Physical attacks can steal HP and mana, determined by those stats:

Make sure those aren’t 0% or else you can’t sustain health and mana properly.

Physical attacks can proc deadly and crushing blow, deadly blow multiplies your physical damage dealt by 1.5x, so it is very important to keep deadly blow% close to 100%, while crushing blow gives your attacks a chance to break the enemy armor, stacking up to 5 times (50% armor break), so another multiplier of 1.5x, but this time to your total damage, since we hit multiple times per second, a crushing blow% above 5% is good enough.

Physical attacks can land critical strikes, which are a chance to multiply your damage by the critical strike damage%, it is very hard to find sources to scale critical strikes, in the endgame this is mainly done by non-unique charms, which are pretty rare, and also getting nerfed in S7, that is another reason why i suggest going for Shadow weapons.

This is how Base damage is calculated, in-game it is represented by this number:

When you use a physical skill, the Base Damage is multiplied by the Skill damage:

Since S7, it is possible to see the Skill damage dealt on the tooltip, so just hover your mouse over Surgical Blood Letting and you will check its Skill damage dealt.

The skill damage dealt is multiplied by other multipliers:

Deadly blow, critical strike damage and armor break were explained beforehand, extra damage to X modifier is the strongest affix in the game, since it is the last multiplier before the damage is done to the enemy.

● Equipment/Gear I highly recommend to only transition into the physical build after you acquire either Shadowfury or Shadow Carver. Those weapons have a special ability called Reaper’s Culling

It multiplies your Base Damage by x2, x2.5 or x3, depending on the Reaper’s Culling level It also makes your hits never miss Getting a +3 Reaper’s Culling is very important, but using a +1 to begin the physical swap is fine as well The downside is not being able to land critical hits Conclusion: With those you will be able to not care about critical strike chance/damage, attack rating, and ignore target defence%, which are usually rough stats to get when progressing a physical build.

I’d also highly recommend getting a Divine Piercing armor augment , it makes Surgeon Vortex blades not disappear when hitting enemies, greatly improving map clear, it is not worth going past level 1 though. In my opinion this is not mandatory to start like a Shadow weapon, but is a huge QOL, getting it on any of the A tier armors listed below is worth it.

Once again, to avoid market manipulation I'm listing multiple viable options to choose, ALL OF THEM ARE GOOD, they are listed randomly, there is no distinction if one is better than the other if they are on the same tier, try to find good opportunities to spend less gold if you’re playing trade.

I'm listing all the good items to use as a tier list from B to S. ● B tier: Good enough to start the transition (don’t use angelic keys on the armors of this tier though) ● A tier: Potentially good for H5 Amun Ra ● S tier: Items to use if you need a further damage boost, items here might be very expensive Remark 1: I’m only considering the impact of those items for damage. Remark 2: I’m not listing mythic/rare items , but all of them can range from A to S tier if they have good affixes , here is a small list of them with the respective maximum rolls: +50 vitality/strength per level | +5 all skills | +75% attack damage +30% extra damage to bleeding | +150% enhanced damage

Item type B Tier A tier S tier

Weapon +1 Reaper’s Culling Shadow Weapon +3 Reaper’s Culling Shadow Weapon More info on Scaling into the endgame page

Shield N.A. N.A. More info on Scaling into the endgame page

Armor Shroud of Enigma runeword Force runeword Cuirass of Blood Anubis Torso Butcher’s Apron Traveler's Leather Jacket

Fortress runeword Cocoon of the Berserker Gladiator’s Demise Leviathan’s Carcass Heaven’s Might Pit Fighter’s Band Shirt Grimbone's Ribcage Isarius Ironthorn Breastplate

Executioner’s Cocoon

Helmet Delirium Tremens runeword Demon Warlord’s Helm Tenebris’ Greviance Butcher’s Hood

Mask of the Beyond Chimera runeword

Legionnaire runeword Harlequinn’s Veil Nikita’s KJ-33 Helmet Eternal Death The Colossal Avenger

Boots Quickstep runeword Bone Conjurer’s Marchers Arena Master’s Marchers

Sonicstep runeword Hermes boots Blood-Letter’s Plated boots Whisper Walker's Feiyue

Crushfleet runeword Violence runeword Brutal Roamers Chaoswalkers

Gloves Lifeward Gauntlets Anubis’ Mighty Hands Scuttle Crab Gauntlets

Razor Knuckles Siege Breakers Pit Fighter’s Bone Crushers

Brawler’s Fighting Mitts

Belt Knight’s Girdle Monkeyskin Belt Rugal’s Sash of Undertaking Commander’s Sash Sun Wukong’s Belt Crystal Belt Butcher’s Belt Tribal Belt

Traveler’s Double Belt Tundra Warrior’s Girdle Cingulum of Shifting Destiny Combat Duty Belt Warbosses’ Trophy Belt Flame Diviner's Cord Komodos Bloodstrap

Belt of Skulls Gladiator King’s Belt Girdle of Eternal War

Amulet Elder’s Heart Kallik’s Fury Claw of the Bloodthirsty Scout’s Medal of Honor Anubis Oculus Rapidshell Medallion

Gambler’s Demise Shining Pearl Light Bringer’s Mark All Seeing Eye Compass of Wealth Gurag's Pebble High Demon's Necklace Traveler's Compass Pyramid Pendant Rift Warrior's Skull

Eagle’s Claw Philosopher’s Stone Tarethiel’s Fall Steve’s Necklace

Rings Colossus circle of Vitality Satanic Eye

Demon Eye Ring (only 1 for the proc) Quickening Zephyr (Plague) Sung Lee’s Unleashed Rage Soulforged Ring Khodo’s Wedding Band Pit Fighter’s Carnage

Giant’s Band of Strength Azazel’s Despair (Anubis) Destroyer’s End Fury of Tarethiel

Charms Crow’s Feather Raider’s Torch Adventurer’s Quiver Witches Claw Hardened Steel Defender Spine Trophy

Tablet of Awakening Anubis’ Ankh Charm Gurag’s Heart Charm Viking's Glyphed Rune

Hello Its me, Steve! Torch of Shadows Torstein’s Anvil Plague Shot Earth Melon

Flasks Elixir of Death Bottle of Sake Radbull

Empty Bottle of Vodka Protein Shake Caffeinated Coffee Container (only good if your mercenary can survive boss fights)

● Attributes 300 points go into Vitality since it's good for both survivability and damage on Plague Doctor, and the other 100 goes into Strength.

● Skill trees Core skill tree:

Above you’re seeing a skill tree with 30 points left, and the reason for that is those points are a personal choice, you can do the following with them: ● First, put points into Devout Doctor until you reach level 20 with it (paying attention to how much +All Skills you have), it is not worth investing more than that. ● Now with your other points: ○ If you want more damage: level up Malpractice ○ If you want more health: level up Lifeblood Aura Example of a tree for maximum damage:

Notice how Devout Doctor is exactly at level 20, and other points went to Malpractice

● Specialization trees

This is the maximum damage setup, if you want more movement speed remove 2 points from Sanguine Eruption, and put 2 points on Swift Precision.

If you really need higher single target damage, try using Blood Thaumaturgist big node instead of Surgeon’s Vortex, the downside is having to sit on top of stuff to land all the knives, but the damage is massive.

Toxic flask massive health+damage buff and also teleport, try keeping it always up

Randy Rider movement speed buff

● Mercenary (Act 3)

The Act 3 Mercenary is pretty impactful for physical builds due to its attack speed buff, eventually you can swap to the Act 1 Mercenary if you want more magic find (using Death's Mirror, The Bucket, Leprechaun's Greed, and Babylon's Fall), but for achieving maximum damage, Act 3 merc is always better: Early-Mid game Merc gear suggestions: Weapon (mandatory): Valkyrie as a 1-handed Throwing runeword (+All skills base if possible) | Used for fanaticism aura Shield: Gem Encrusted Tower | Makes your merc very tanky while giving 6 sockets to place runes such as Ist (Magic Find) Armor: Runemaster’s Mantle | Place 6 Ist runes and you have a magic find armour Helmet: Delirium Tremens (+All skills base if possible) | Gives a LOT of skill levels so you get more attack speed from the buff, also gives mana stolen per hit, sustaining the merc's mana Boots: Treasure Hunter’s Boots Gloves: Midas’ Hands Belt: Belt of Infinite Wealth

● Hero Level tree

After getting through this path, you unlock the 2 charm slots, other points are a personal choice, if you want character power go for attributes on the top, or if you want to do a farming strategy with glyphs, invest points into it.

● Trick to abuse Extra Damage to Burning affix from Coffee Container

We do this by using a Molten Paw on our weapon swap, the fire enchant skill makes some attacks be able to burn, for some reason Surgical blood letting doesn’t burn, so this is useful only to make our mercenary burn with its basic attacks.

Equip it into your second weapon set, swap to it during a fight, cast fire enchant, and swap back to your main weapon, now the merc’s basic attacks will burn, so you can use the coffee container potion for a huge damage increase.

Scaling into the endgame

Endgame Scaling

At this point you unlocked Inferno with the non-crit build, which is very easy to scale to this point since you have less stats to care about, but as you start getting better gear, scaling critical strikes becomes the better option for damage, so this section of the guide will give more details on how to transition from a non-crit Shadow weapon build to a endgame crit-based physical Plague Doctor.

Relics to look for (maximum damage): Skull Axe | Nunchucks | Twin Blade | Razer Blade Keep in mind after swapping out of a +3 Reaper’s Culling weapon, you will lose a x3 multiplier to your base damage, so i highly recommend to get more critical strike chance and critical strike multiplier than the table below before swapping to a critical strike build:

Critical strike chance and damage % that are the equivalent to a +3 Reaper’s Culling weapon Critical strike chance % Critical strike damage % 95 200 90 211 80 223 70 271 60 316 50 380 40 475 30 633

Everything is updated according to how the items look like in S8 open beta, but feel free to contact me if i missed something.

I'm listing all the good items to use as a tier list from B to S. ● B tier: Items that aren’t very impactful but are decent ● A tier: Very good items ● S tier: Best in Slot contenders Remark 1: I’m only considering the impact of those items for damage. Remark 2: I’m not listing mythic/rare items , but all of them can range from A to S tier if they have good affixes , here is a small list of them with the respective maximum rolls: +5 all skills | +50% critical strike damage +30% extra damage to bleeding | +150% enhanced damage

Item type B Tier A tier S tier

Weapon Sidewinder Monsoon Grimbone’s Scythe Glowstick Estoc

AK-47 Pit Fighter’s Skullcracker Stormslayer The Hope Ender

Glock 22 St. Amitiel’s Truth St. Soloyolo’s Holy Bow Feral runeword (+%attack speed

Candy Shredder Headsman’s Bloodthirster Luci’s Day Gurag's Stone Crusher The Light of Dawn St. Neri’s Rainbow Lance Genji’s Sword of Fate Scarred Battle Darts Pit Fighter’s Brutalizer Abomination's Gut Ripper Bonetti's Rapier Arachno Phobia Astral Projector Wind's Force Brimskull Trident Gabriel's Broken Resolve

Blood Moon Crescent St. Gabriel’s Retribution St. Mika’s Zweihander St. Draxis Longsaw St. Draxis Pigstick St. Rexis Sundering Axe Aurelion Fury Dracula's Demise Deathquill Vorpal Sharktooth Rakhul’s Legion Crusher Eden’s Harvester

base with 1.75 attacks per second) Eternity

Shield Tombstone Defender’s Justice

Gladiator’s Wall Rendguard of Carnage Demon’s Mirror St. Hallgar’s Bloodforged Aegis

Pit Ravager’s Cetratus St. Tomi’s Vibrant Aura

Armor Fortress runeword Cocoon of the Berserker Gladiator’s Demise Leviathan’s Carcass Heaven’s Might Pit Fighter’s Band Shirt Grimbone's Ribcage Isarius Ironthorn Breastplate

Executioner’s Cocoon Gabriel’s Broken Wings

Tayrel’s Chestplate

Helmet Mask of the Beyond Chimera runeword

Legionnaire runeword Harlequinn’s Veil Nikita’s KJ-33 Helmet Eternal Death Pit Lord’s Vanquisher

High Roller’s Deathcrown (+777) Legionnaire runeword (+5 all skills or +critical strike damage base) The Colossal Avenger

Boots Sonicstep runeword Hermes boots Blood-Letter’s Plated boots Whisper Walker's Feiyue

Crushfleet runeword Steampowered Flamewalkers

Violence runeword Brutal Roamers Chaoswalkers

Gloves Razor Knuckles Siege Breakers Pit Fighter’s Bone Crushers

Brawler’s Fighting Mitts Rimskin Assassins St. Ahto’s Diamond Hands

Belt Traveler’s Double Belt Tundra Warrior’s Girdle Cingulum of Shifting Destiny Combat Duty Belt Warbosses’ Trophy Belt

Vagabond’s Strap Belt of Skulls Flame Diviner's Cord Komodos Bloodstrap

Gladiator King’s Belt Girdle of Eternal War El Patrón’s Madness Liquor Holster

Amulet Gambler’s Demise Shining Pearl Light Bringer’s Mark All Seeing Eye Anubis Oculus Compass of Wealth Elder’s Heart Gurag's Pebble High Demon's Necklace Traveler's Compass Pyramid Pendant

Eagle’s Claw Philosopher’s Stone Tarethiel’s Fall Raven’s Claw

Steve’s Necklace Gryphon’s Claw Signet of Kadosh Amulet of Colosseum

Rift Warrior's Skull

Rings Quickening Zephyr (Plague) Elven Grace Soulforged Ring Pit Fighter’s Carnage Giant’s Band of Strength

Destroyer’s End Fury of Tarethiel

Azazel’s Despair (Anubis)

Charms Crow’s Feather Raider’s Torch Adventurer’s Quiver Witches Claw Hardened Steel Defender Spine Trophy Anubis’ Ankh Charm Gurag’s Heart Charm

Tablet of Awakening Plague Shot Overloaded Dice Viking's Glyphed Rune

Hello Its me, Steve! Torch of Shadows Torstein’s Anvil Earth Melon Annihilator Chaos Gemstone Devil's Pact Mysterious Monkey Paw Soul Collector Gladiator’s Dice Fulgurite

Flasks Elixir of Death Bottle of Sake Radbull

Empty Bottle of Vodka Protein Shake Caffeinated Coffee Container (only good if your mercenary can survive boss fights)

Best in Slot items

Best in Slot item sets

From my testing, this is what i believe are the best items you can use to achieve the highest possible damage with physical Plague Doctor

Weapon: Feral (1.75 base attack speed with +30% increased attack speed) Shield: St. Tomi’s Vibrant Aura Helmet: Lucifer’s Crown (this item is completely insane) Armor: Tayrel's Chestplate Gloves: Rimskin Assassins Boots: Chaoswalkers Belt: El Patrón's Madness Amulet: Steve’s Necklace Rings: 2x Azazel's Despair (Anubis Soulgem) Charm setup: Overloaded Dice (+1 to Surgical Blood Letting) Earth Melon Hello its me, Steve! Soul Collector Annihilator Fulgurite Torch of Shadows (+3 Plague Doctor) Gladiator’s Dice Chaos Gemstone (with high critical strike damage or extra damage to bleeding) 2x Grand Charms: +25% critical strike damage or +5 to all skills (Plague Doctor) or +100% enhanced damage Potions: Protein Shake | Bottle of Sake | Empty bottle of Vodka | Caffeinated Coffee Container (make sure to use molten paw swap) Relics (QoL/balanced): Skull Axe | Shiv | Death’s Scythe | Jefre’s Subscription | Razer Blade

Charm layout

Cover page

Welcome to my Plague Doctor guide for Season 8!

This guide covers the physical attacker archetype , if you’re looking for the poison caster build, check my other video. Youtube channel: https://www.youtube.com/@Proerd-iKappa

Important: For a better reading experience do the following:

Click on View; hover over Text width; then click on Wide This should make the guide better to read

Plague Doctor is a DLC class in Hero Siege, featuring options to play as a poison-themed spell caster or a knife throwing/stabber physical attacker.

It was one of the best classes in Season 5, 6, 7, and will be one of the best in Season 8 as well. I'm dedicating a page to talk about what changed in Season 8 and how it impacts us.

Helpful content below:

What changed in S8?

What changed in Season 8?

(Only covering big changes related to character power that affects mainly Plague Doctor’s physical build)

really nice one

A small buff to the physical build.

Molten Paw swap is only useful now for bossing, since only the merc’s basic attacks will be able to burn.

FAQ and Loot filters

FAQ Frequently asked questions | Loot filters (highlight only)

What relics to use?

Relics changed a lot in S8, feel free to experiment with them, here is my personal choice looking at them:

Setup 3 Meant to use with a non-shadow weapon for maximum damage Skull Axe | Nunchucks | Twin Blade | Razer Blade

Setup 4 Defensive setup Cheese Burger | Mayo’s Old Sock | Cookies & Milk | Skull Axe

What armor augment to choose? (Angelic Key)

What to do on the Hero Level skill tree?

Find hero level skill trees at the Leveling progression page for the Poison leveling build, and Transition to physical page for the physical build.

What to do with free sockets? (Physical build)

How to distribute attribute points?

What mercenaries to choose?

For poison build use the Act 1 mercenary (skill tree in Leveling progression page) For physical build use the Act 3 mercenary (skill tree in Physical build transition page)

What loot filters to use?

Loot filters got updated in S8.

Leveling progression

Leveling progression as Plague Doctor

Tip: When changing equipment, ALWAYS look at your damage tooltip (hover your mouse over your skill), be careful to not reduce your damage.

Level 1 24: Put all your points into Crematus until maxed, then other points into Toxic Flask

Level 24-39: Here you start using two skill trees, #1 for zone clear and #2 for act bosses and bloating mobs.

Tree #1 Zone Clear Tree #2 Act bosses + Bloatings

20 points into Plague Master [Careful since it uses a lot of mana (get at least 200 mana)]

Other points into Chant of Weakness

On level 35 unlock the Toxic Flask teleport specialization (Flask Flip)

20 points into Jar of Leeches

Other points into Plague of Rats

Plague of Rats is an optional skill choice for bosses, with the Rat Den node you can keep enemies with a 25% higher poison break compared to Crematus poison break, giving you a slight damage boost.

20 points into Crematus

1 point into Toxic Flask

1 point into Oops

1 point into Plague of Rats

1 point into Exploding Mice

15 points into Jar of Leeches

1 point into Randy the Rancid Rat

Pictures of the specialization trees below:

Level 40-100: Based on the level 40 respec tree above, do the instructions below in order from top to bottom and you will be fine until level 100:

Max Jar of Leeches

Max Chant of Weakness

Max Crow Mask’s Presence

1 point into Lifeblood Aura

With the 14 points you have left, there are two options, pick whatever you prefer:

Put 14 points into Toxic Flask for more Crematus damage

Put 14 points into Lifeblood Aura for more Health

Toxic Flask: 5/5 Agile Tosser 1/5 One with the Poison 2/3 Vial of Alchemy (Level 70) 5/5 One with the Poison 3/5 Flask flip 3/3 Vial of Alchemy (Level 100)

Plague of Rats: 5/5 Leptospirosis 3/5 Plague Carriers 2/3 Rat Den (Level 70) 5/5 Plague Carriers 5/5 Horde of Rats 3/3 Rat Den (Level 100)

Jar of Leeches: 5/5 Leech Swarm 1/5 Blood Sharing 2/3 Lasting Hunger (Level 70) 5/5 Power Sucktion 2/5 Bloody Surprise 3/3 Lasting Hunger (Level 100)

Randy the Rancid Rat: 2/3 Randy Rider (Level 70) 3/3 Randy Rider (Level 100)

Use the screenshots below as a reference to how the build should look like at level 100:

Alternative spec skill tree for Crematus (better on zones that you aren’t instakilling stuff))

Hero Level skill tree:

1st step is grabbing those

2nd step is going all the way up and grabbing those

3rd step is either grabbing those points or going for the charm slots, personal and situational choice Mercenary skill tree (Act 1): Use magic find items on him if possible

Midgame progression

Midgame progression with the Poison build

This section of the guide will be focused on gearing progression and important mechanics to consider when choosing the items.

Everything is updated according to how the items look like in S8 open beta, but feel free to contact me if i missed something.

Item type B Tier A tier S tier

Weapon Cobra Blood Vial Skysong runeword (1 handed) Wormclaw Sands of Time Voodoo Magician's Skull Brilliance runeword

Clafaxier Doomweed Vial Divinity runeword Dragon Knight's Flail Deathquill Thorn of Helheim Damien's Head God's Benevolence

Shield Skysong runeword Pandemic Shield Arcane bastion runeword Novice’s Tower

Ancient Aegis Defender’s Justice Ward of Toxicity Heaven’s Champion

Bubonic Plague’s Pledge runeword

Shadow Buckler Iron Giants Shield Battle Mage’s Shield Spellbinder’s Magebarrier Suomi Finland Suatana

Suomi Finland Perkele Aztec Ward

Armor Toxicarcus runeword Shroud of Enigma runeword Mystify runeword Magister’s Robe Hazmat Suit Arcane Robes of Authority Scourge Gladiator’s Armor Grandwizard’s Robe

Heaven’s Might Grimbone's Ribcage Isarius Ironthorn Breastplate Mystique Allure Stoneplate of Corruption Traveler's Leather Jacket

Gem King’s Garb (Pristine emerald) Noxious Hunter’s Reward Sheep King’s Hide Venomsteel Carapace Wraith’s Cloak (Poison) Dragon Knight's Vanguard Exiled Pagan’s Mantle

Helmet Chimera runeword Harlequinn’s Crest

Crown of Midnight The Curator of Secrets

Sheep King’s Crown Eternal Death Sight of the Gods Curse runeword Delirium Tremens runeword Nirvana runeword Grimbone’s Visage Harlequinn’s Veil

Boots Paradox runeword Ghost runeword Hermes boots Mana-woven walkers Arch Wizard’s Silk Boots

Ninja tabi runeword Marchers of Hatred Adamant Roamers Pearlescent Dream Voodoo Stompers Grand Wizard’s Silk Shoes Wind Walker’s Step

Etherwalk runeword (poison)

Gloves Conjurer Mitts Battle Caster’s Gauntlets Lifeward Gauntlets

Mevius’ Mighty Gauntlets (Poison) Anubis’ Mighty Hands Wisdom’s Hold

Shadow Occultist’s Wraps Spellweavers (Poison) Fighter Magi’s Grips Plague Bringer’s Touch

Belt Lich Sash Crystal Belt Commander’s Sash Knight’s Girdle Sash of the Magi Runemaster’s Waistwrap Traveler's Double Belt

Tether of Anguish Cingulum of Shifting Destiny Komodo’s Bloodstrap (poison) Trophy Hunter

Girdle of Eternal War (Poison) Majorie’s Belt

Amulet Damien’s Soulstone High Demon’s Necklace Arcana Eye Gambler’s Demise Rapidshell Medallion Ritual Pendant Shining Pearl Serpentine Necklace

Aztec Necklace Visage’s Eye All seeing eye Claw of the Hunter Rift Warrior’s Skull Light Bringer’s Mark Lilith’s Scorn Traveler’s Compass Unfathomable Puzzle Venom’s Necklace

Steve’s Necklace Philosopher’s Stone Pendant of Eternity Tarethiel’s Fall

Rings Satanic Eye Swiftsoul Band Viper’s Seal of Corrosion Merlock’s Halo Circle of Nature

Khodo’s Wedding Band Iron Ring of Prometheus Mark of Ferocity Ring of Tallus Stone of Premonition

Giant’s Band of Strength Quickening Zephyr (Plague Doctor) Soulforged Ring Signet of Corruption The Absence of Constraint

Charms Damien’s Cage Traveler’s Map Journal Crow’s Feather

Doctor’s Mask in a Jar Loaded Dice Shrunken Head Witches Claw

Apple of Evolution Hello Its me, Steve! Torstein’s Anvil Tablet of Awakening Chaos Gemstone Devil’s Pact Overloaded Dice Mysterious Monkey Paw Rotten Pumpkin Dragon’s Heart

Annihilator Fulgurite Torch of Shadows Sheep King’s Wool Wizard’s Dice Sassy’s Dislocated Foot Tarethiel’s Ancient Wisdom Soul Collector

Flasks Ghostly Potion Elixir of Death Wizard Potion

Empty Bottle of Vodka

Key advices before fighting H5 Uber Reaper

● The “Shadow Skull” attack is very hard to dodge, it's better to just tank it, due to that i recommend you get around 4k health and 75% arcane resistance before fighting it

OUTDATED!!!

Physical build transition

Transitioning into the Physical build

Time to swap into a completely different Plague Doctor build.

● Core mechanics explained:

The skills used here are the following:

Surgical Blood Letting as the main damage dealer

Toxic Flask used to teleport and buff our health and damage by a massive amount

Defunct Surgeon used to give a small attack speed buff

Randy the Rancid Rat used to give a movement speed buff

The main skill of this build is Surgical Blood Letting, a physical attack with built-in Vitality damage scaling through a specialization node.

Physical attack rate is based off your weapon’s base attack speed, and it can be increased by raising your %increased attack speed:

The bottom stat is the global increased attack speed, which is multiplied by 0,75 before being added into the attacks per second stat

Physical attacks can miss enemies, and what determines if you hit an enemy is their defence compared to your attack rating, enemies defence scale exponentially based on zone level, that is one of the reasons we are using Shadow weapons at the beginning of the transition, to not care about that stat since they give 100% hit chance.

Physical attacks can steal HP and mana, determined by those stats:

Make sure those aren’t 0% or else you can’t sustain health and mana properly.

Physical attacks can proc deadly and crushing blow, deadly blow multiplies your physical damage dealt by 1.5x, so it is very important to keep deadly blow% close to 100%, while crushing blow gives your attacks a chance to break the enemy armor, stacking up to 5 times (50% armor break), so another multiplier of 1.5x, but this time to your total damage, since we hit multiple times per second, a crushing blow% above 5% is good enough.

Physical attacks can land critical strikes, which are a chance to multiply your damage by the critical strike damage%, it is very hard to find sources to scale critical strikes, in the endgame this is mainly done by non-unique charms, which are pretty rare, and also getting nerfed in S7, that is another reason why i suggest going for Shadow weapons.